Discovering Endophenotypes for Major Depression
نویسندگان
چکیده
منابع مشابه
Rhythmicity in Mice Selected for Extremes in Stress Reactivity: Behavioural, Endocrine and Sleep Changes Resembling Endophenotypes of Major Depression
BACKGROUND Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, including hyper- or hypo-activity of the stress hormone system, plays a critical role in the pathophysiology of mood disorders such as major depression (MD). Further biological hallmarks of MD are disturbances in circadian rhythms and sleep architecture. Applying a translational approach, an animal model has recently bee...
متن کامل[Endophenotypes of the biorhythms and the sleep in depression].
Chronobiological markers of depression display a biological desynchronization which participates in the pathogenesis of depression. Mood disorders and clock genes have shown significant associations suggesting a possible pathogenetic link between them, providing a privileged base for exploring biorhythmic endophenotypes. They would be useful indicators of vulnerability mechanisms, giving rise t...
متن کامل[Major depression invites major concerns].
OBJECTIVE To overview limitations to the concept and construct of major depression. METHOD The objectives in initially conceptualizing major depression are examined against its subsequent utility and relevance to clinicians and researchers. RESULTS It is argued that, as defined, major depression does not differentiate clinical depression well from expressions of non-clinical depression or s...
متن کاملRaphe nuclei echogenicity changes in major depression
Background: Major depression is a common disorder with great social and individual burdens. Transcranial sonography (TCS) is a useful and noninvasive measure for assessment of normal and impaired brain parenchyma. The brainstem raphe nuclei are in close association with dorsocaudal limbic system and plays an important role in depression. In this study we compared the echogenicity of the r...
متن کاملMagnesium in major depression.
There are contradictory data regarding the levels of magnesium in patients with major depression (MD) and how antidepressants influence their concentration. Our results show erythrocyte magnesium in patients with MD (44.39 +/- 2.7 mg/L vs. 59.1 +/- 3.2 mg/L in control group, p < 0.05) and only in patients with severe MD (Hamilton score > 23) was a moderate decrease in plasmatic magnesium observ...
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ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 2004
ISSN: 0893-133X,1740-634X
DOI: 10.1038/sj.npp.1300506